Loading...
Cytotoxic lasiodiplodin derivatives from the fungus Syncephalastrum racemosum
Author(s)
Buayairaksa, Mongkol
Kanokmedhakul, Somdej
Kanokmedhakul, Kwanjai
Moosophon, Panawan
Hahnvajanawong, Chariya
Date Issued
December 1, 2011
Type
Article
Abstract
Chemical investigation of fungal biomass of the fungus Syncephalastrum racemosum led to the isolation of new natural products (3R),(5S)-5-hydroxy-de-O- methyllasiodiplodin (1), 6-oxode- O-methyllasiodiplodin (2), in addition to five known compounds, de-O-methyllasiodiplodin (3), lasiodiplodin (4), (3R),(5R)-5-hydroxy-de-O-methyllasiodiplodin (5), ergosterol (6), and ergosterol peroxide (7). Their structures were elucidated by spectroscopic techniques. The absolute configuration of 1 was determined by a modified Mosher's method. Compound 1 showed cytotoxicity against cholangiocarcinoma, KKU-M139, KKU-M156, and KKU-M213 cell lines with IC50 values in the range of 14-19 μg/mL, while 3 showed cytotoxicity against KB, BC1, and NCI-H187 cell lines with IC50 values of 12.67, 9.65, and 11.07 μg/mL, respectively.
Citation
Archives of Pharmacal Research, 34(12), 2037-2041, 2011