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Superparamagnetic nanoparticles encapsulation via droplet-based microfluidics for targeted drug delivery system
Author(s)
Date Issued
January 1, 2019
Type
Conference Paper
Abstract
Here, we present monodispersed superparamagnetic iron oxide nanoparticles (SPIONs)-loaded poly(lactic-coglycolic acid) (PLGA) microdroplets encapsulation by a microfluidic flow-focusing device. SPIONs in PVA solution were employed as a continuous phase and the mixture of PLGA in dichloromethane (DCM) was employed as a disperse phase in the droplet-based microfluidic system. The diameter of microdroplet was carefully controlled and optimize by flow ratio between the dispersed phase and the continuous phase in the microfluidic system. The formation of monodispersed SPIONs-loaded PLGA microdroplet is a matrix particle structure. The magnetization property of microdroplets was characterized and the external magnetic field induced microdroplet also was performed.
Citation
23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences Microtas 2019, 981-982, 2019