Soytong, Kasem

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Soytong, Kasem
Alternative Name
Soytong, K.
Email
kasem.so@kmitl.ac.th

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    Item type:Publication,
    Bioactive azaphilones from the fungus Penicillium multicolor CM01
    (2016-06-01)
    Hemtasin, Chulida
    ;
    Kanokmedhakul, Somdej
    ;
    Moosophon, Panawan
    ;
    Soytong, Kasem
    ;
    Kanokmedhakul, Kwanjai
    Two new azaphilones, dechloroisochromophilone II (1) and epi-isochromophilone III (2), a new natural product, 5-hydroxy-4-methoxy-5,6-dihydro-2H-pyran-2-one (3), together with eleven known compounds, 4-14 were isolated from the fungus, Penicillium multicolor CM01. Their structures were elucidated by spectroscopic methods. Compounds 2, 8, 10 and 11 exhibited antimalarial activity against Plasmodium falciparum (IC<inf>50</inf> 2.1-7.8 μg/mL), while compounds 9 and 10 showed antimycobacterial activity against Mycobacterium tuberculosis (MIC 6.2 and 50.0 μg/mL, respectively). Compounds 2, 4, and 7-11 showed cytotoxicity against three cancer cell lines, KB, MCF-7 and NCI-H187 (IC<inf>50</inf> 2.2-35.2 μg/mL). In addition, compounds 1, 5-8 and 11 showed a minimum inhibition requirement to acetylcholinesterase (AChE) assay in the range of 0.03-0.25 nM.
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    Item type:Publication,
    Bioactive meroterpenoids and alkaloids from the fungus Eurotium chevalieri
    (2011-07-29)
    Kanokmedhakul, Kwanjai
    ;
    Kanokmedhakul, Somdej
    ;
    Suwannatrai, Ruchiruttikorn
    ;
    Soytong, Kasem
    ;
    Prabpai, Samran
    Five new meroterpenoids, chevalones A-D (1-4), aszonapyrone B (8), and a new sequiterpene alkaloid, eurochevalierine (5), together with four known compounds, sequiterpene (6), terpenoid pyrrolobenzoxazine named CJ-12662 (7), meroterpenoid, aszonapyrone A (9), and ergosterol were isolated from the fungus Eurotium chevalieri. The structures were established on the basis of spectroscopic evidence. The configurations of 1 and 5 were determined by X-ray analysis. The biosynthetic pathway of 1-3, 8, and 9 were proposed. Chemical transformation of aszonapyrone A (9) was also studied. Compounds 4, 5, and 7 exhibited antimalarial activity against Plasmodium falciparum, while 3, 5, and 7 showed antimycobacterial activity against Mycobacterium tuberculosis. In addition, compounds 2-7 showed cytotoxicity against cancer cell lines. © 2011 Elsevier Ltd. All rights reserved.