Monvisade, Pathavuth

Preferred name

Alternative Name

Monvisade, P.

Main Affiliation

School of Science

pathavuth.mo@kmitl.ac.th

Now showing 1 - 10 of 16

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Colorimetric Screen-Printed Label Using Low Molecular Weight Chitosan Grafted with Rosolic Acid for pH and Ammonia Gas Sensing
(2024-10-15)
Ronte, Arnat
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Chalitangkoon, Jongjit
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Monvisade, Pathavuth
Colorimetric sensing technologies are valued for their simplicity and adaptability, yet their large-scale production remains economically challenging. This study presents a cost-effective colorimetric pH sensor developed from low molecular weight chitosan (LC) grafted with rosolic acid (LCRA), engineered as a pH-sensitive colorant for screen-printing inks. LCRA was synthesized via a Mannich reaction and characterized using1 H NMR, FT-IR, and UV-Vis spectroscopy. LCRA showed reduced crystallinity and thermal stability alongside notable improvements in water solubility compared to its LC precursor. The LCRA ink displayed compatibility with various substrates, including polypropylene spun bond, filter paper, and cotton, applying easily via screen printing without any dye leaching. Notably, it exhibited a responsive color change from orange-yellow to pink-red in response to pH adjustments between 4.0 and 12.0 and upon exposure to ammonia gas. These findings position the LCRA label as a versatile and efficient solution for visual pH detection across various applications.
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Antimicrobial nanolayer films of chloroxylenol–carboxyethylchitosan–modified silver nanoparticles for enhanced surgical suture performance
(2024-07-20)
Chittratan, Pakawat
;
Detsri, Ekarat
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Chalitangkoon, Jongjit
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Mathaweesansurn, Arjnarong
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Monvisade, Pathavuth
Antimicrobial surgical suture materials incorporating chloroxylenol-carboxyethylchitosan-modified silver nanoparticles (CECSX-AgNPs) were successfully prepared using the Layer-by-Layer (LbL) deposition technique. Chitosan (CS) was covalently affixed with chloroxylenol as hydrophobic functional groups (PCMX), yielding chloroxylenol-chitosan (CSX) and later hydrophilic acrylic acid onto the CSX skeleton, providing a novel water-soluble antimicrobial agent of chloroxylenol-carboxyethylchitosan (CECSX). 1H NMR confirmed the successful substitution of PCMX and acrylic acid onto CS, with %DS<inf>PCMX</inf> and %DS<inf>AA</inf> of 8.0 and 33.0, respectively. CECSX successfully stabilized AgNPs via the chemical reduction method, resulting in CECSX modified AgNPs. The colloidal solution exhibited a yellowish hue, spherical shape, monodispersity with an average particle size of 4.8 ± 2.4 nm, and a zeta potential value of −20.97 ± 0.03 mV. Minimum inhibitory concentration (MIC) values for CECSX-AgNPs against E. coli (ATCC25922), S. aureus (ATCC25923), and A. baumanii (ATCC19606) were determined as 25, 12.5, and 1.56 mg/L, respectively. Using the LbL deposition technique, CECSX-AgNPs were successfully deposited onto various suture materials including cotton, polyamide, and polypropylene. Remarkably, CECSX-AgNPs coated surgical sutures exhibited the highest bacterial reduction of 99.99 %. These findings underscore the efficacy of CECSX as a high-performance stabilizing agent for AgNPs production, providing outstanding antibacterial activity on diverse surgical suture materials and promoting the wound healing process.
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New Chitosan-Grafted Thymol Coated on Gold Nanoparticles for Control of Cariogenic Bacteria in the Oral Cavity
(2022-08-02)
Chittratan, Pakawat
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Chalitangkoon, Jongjit
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Wongsariya, Karn
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Mathaweesansurn, Arjnarong
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Detsri, Ekarat
Chitosan-grafted thymol (CST) coated on gold nanoparticles has been synthesized and characterized for the design of antimicrobial materials. CST was synthesized via adapting the Mannich reaction, and it acted as the capping agent for the synthesis of gold nanoparticles (AuNPs). The grafting of thymol onto the side chain of chitosan has provided a degree of substitution value (%DS<inf>NMR</inf>) of 10.0%, calculated by nuclear magnetic resonance spectroscopy. UV-visible spectrometry and elemental analysis were used to confirm the successful synthesis of CST through adapting the Mannich reaction. The appropriate concentration of CST for AuNP synthesis was found to be 0.020%w/v. A red-wine colloidal AuNP solution of 2.41-3.30 nM particle size exhibits a strong surface plasmon resonance at 502 nm, which shows negative charges at pH = 9 of -36.37 mV. This result evidenced that the AuNPs showed electrostatic repulsion and CST played a role as a capping agent to provide a good dispersion and stability state. CST coated on the AuNP surface was successfully utilized for the control of cariogenic bacteria in the oral cavity. The results obtained from this study show that the tuning of the capping agent used in the synthesis step strongly influences the latter antimicrobial activity of the nanoparticles against Streptococcus mutans ATCC 25175 and Streptococcus sobrinus ATCC 33402 activity, with an inhibition zone of 15.90 and 14.25 mm, respectively. The average minimum inhibitory concentration values against S. mutans ATCC 25175 and S. sobrinus ATCC 33402 were found to be 25 and 100 mg/L, respectively, whereas the minimum bactericidal concentration values were 100 and 200 mg/L, respectively.
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Silver loaded hydroxyethylacryl chitosan/sodium alginate hydrogel films for controlled drug release wound dressings
(2020-09-15)
Chalitangkoon, Jongjit
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Wongkittisin, Marisa
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Monvisade, Pathavuth
Wound dressings composed of hydroxyethylacryl chitosan (HC) and sodium alginate (SA) were developed with antibacterial activity by loading Ag particles. The formation of Ag particle in the HC/SA films was achieved by an immersion method through in situ chemical reduction of AgNO<inf>3</inf> solution and confirmed by FTIR, SEM-EDS, XRD and XRF techniques. The effect of Ag loading in the Ca-crosslinked HC/SA films with different crosslinking density was studied on swelling behavior, mechanical properties, cytotoxicity, antibacterial activity and drug release behavior. The results showed that Ag loading increased swelling degree in phosphate buffer and enhanced mechanical properties. The HC/SA films with Ag loading exhibited antibacterial activity against E. coli and S. aureus as well as no toxicity on Vero cell. In vitro drug release profiles of the films were examined using para-acetylaminophenol, as a soluble model drug. The increase in crosslinking density and Ag loading prolonged drug releasing rate and almost the films showed linearity profiles. It can be concluded that the HC/SA films with Ag loading have a promising potential in modern wound dressings with antibacterial property and controlled drug release.
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Enhancing chitosan solubility in alcohol: water mixtures for film-forming systems releasing with turmeric extracts
(2021-06-01)
Huaytragul, Janjira
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Chalitangkoon, Jongjit
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Monvisade, Pathavuth
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Chotsaeng, Nawasit
Background: Film-forming system (FFS), a non-solid dosage form, are attractive drug delivery system for the topical drug administration due to ability to form a film in situ on a skin after spraying or applying. To minimize drying time, alcohol is often used as a solvent in the system. The aim of this research was to enhance chitosan solubility in alcoholic solution by chemical modification of chitosan, i.e., reductive amination and Michael addition reaction, for film-forming systems with efficient releasing of turmeric extract. Methods: Alcoholic-soluble chitosan derivative (CBA) was synthesized by reductive amination, followed by a Michael reaction. Its structure was investigated by FT-IR, 1H NMR and XRD techniques. The CBA was incorporated with β-cyclodextrin encapsulated turmeric extract (CDTE) to prepare film-forming solution. Significant Findings: The results confirmed that the CBA was successful prepared, as the new peaks were observed by FT-IR and 1H NMR, with good solubility in 50% aqueous alcoholic solution. The CBA-based film, derived from the solvent evaporation, exhibited nontoxic to HaCaT cells. Moreover, the films containing CDTE had smooth surfaces and released turmeric extract (74%) more effectively than films containing the extract alone (43%). The CBA-based ethanolic solution (30–50%v/v ethanol) could dry within ~6–9 min and form a thin film on human skin. Conclusions: Thus, the CBA-based solution with CDTE has potential as a film-forming system based on natural products.
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Development of a pH-responsive intelligent label using low molecular weight chitosan grafted with phenol red for food packaging applications
(2024-05-01)
Ronte, Arnat
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Chalitangkoon, Jongjit
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Foster, E. Johan
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Monvisade, Pathavuth
In this study, we successfully developed a screen-printed pH-responsive intelligent label using low molecular weight chitosan grafted with phenol red (LCPR) as a colorant for screen printing ink. The LCPR was synthesized via a Mannich reaction, and its successful grafting was confirmed through FT-IR, UV–vis, and NMR spectroscopy. The LCPR exhibited lower crystallinity and thermal stability compared to low molecular weight chitosan (LC) and demonstrated zwitterionic behavior. To create intelligent labels, the LCPR-based ink was efficiently printed on cotton substrates with high resolution. The label exhibited remarkable sensitivity to buffer pH solutions and ammonia gas, leading to distinctive color changes from orange to red to purple. Additionally, the label showed excellent reversibility, storage stability, and leaching resistance to different food simulant solutions. The label was utilized to monitor shrimp freshness, successfully detecting a noticeable color shift upon spoilage. These findings highlight the significant potential of the LCPR-based label as an intelligent food packaging solution, offering pH-responsiveness and color stability for qualitative freshness detection of protein-rich food.
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Improving the Fluorescence of Carbon Dots Through Boron and Silver Doping: A Single-Step Microwave Synthesis Approach
(2024-04-15)
Sakboriboon, Yanika
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Chalitangkoon, Jongjit
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Monvisade, Pathavuth
Carbon dots (CDs) are a promising type of fluorophore with numerous advantages such as low toxicity, biocompatibility, good photostability, and ease of synthesis. However, their low quantum yields (QYs) have limited their applicability in many fields. Researchers have turned to doping CDs with nonmetallic and metallic atoms to address this issue. In this study, we synthesized citric acid/urea-based CDs doped with boron and/or silver atoms in a single step using microwave irradiation. Transmission electron microscopy (TEM) and Fourier transform infrared spectroscopy (FTIR) were used to characterize the CDs. In contrast, UV-visible (UV-Vis) and fluorescence spectroscopy were used to examine their optical properties. We discovered that all synthesized CDs were transparent to visible light and emitted blue fluorescence when exposed to UV light. Our fluorescence analysis revealed that doping with both boron and silver atoms led to higher fluorescence compared to doping with only one of the atoms. Specifically, the quantum yields (QYs) of silver/boron-doped CDs were 26%, which is higher than those of silver-doped CDs (19%), boron-doped CDs (9%), and undoped CDs (6%). These findings suggest that the silver/boron-doped CDs produced using our simple method could be promising materials for sensors and biomedical applications.
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Advanced chitosan hybrid dye labels for dynamic monitoring of shrimp and milk freshness
(2025-04-01)
Ronte, Arnat
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Chalitangkoon, Jongjit
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Sintoppun, Tanaporn
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Niemhom, Nantawan
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Manapradit, Nuttaporn
This study presents the development of intelligent screen-printed labels for real-time food freshness monitoring. Using chitosan grafted with rosolic acid (RA) and immobilized on montmorillonite (MMT) through cationic exchange, a hybrid dye was synthesized and applied in screen-printing inks. The hybrid structure was characterized by XRD, TGA, and UV–vis, confirming improved thermal stability and maintained halochromic properties. SEM analysis showed consistent ink deposition on filter paper, while water contact angle (WCA) measurements demonstrated enhanced surface hydrophobicity due to the MMT. The labels exhibited clear pH-sensitive color transitions from yellow to purplish red (pH 2.0–12.0) and rapid ammonia sensitivity, with ΔE values exceeding 45.0 within 10 min. The labels also demonstrated excellent reversibility, storage stability, leaching resistance, and cytocompatibility. Practical tests on shrimp and milk confirmed the labels' ability to accurately monitor freshness through visible color changes. These findings highlight the potential of hybrid labels as effective, scalable freshness indicators for intelligent food packaging.
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Smart dual-mode fluorescent label from rhodamine–alginate and fluorescein–chitosan for real-time shrimp freshness monitoring
(2026-01-15)
Jitjamrasrat, Aorawee
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Chalitangkoon, Jongjit
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Monvisade, Pathavuth
A dual-mode pH-responsive label was developed for real-time visual monitoring of shrimp freshness. The system integrates oxidized sodium alginate grafted with rhodamine B ethylenediamine (ORE) and chitosan grafted with fluorescein (CSF) into screen-printable inks, forming a dual-color platform with complementary colorimetric and inverse ratiometric fluorescence responses, where ORE emission decreases while CSF emission increases with rising pH. This inverse behavior enhances visual contrast and enables intuitive color discrimination. The label exhibited reversible color transitions—from pink to yellow (daylight) and from bright orange to green (UV) in response to pH and volatile amines showing high sensitivity, selectivity, and storage stability. Applied to shrimp packaging, its optical response correlated with total volatile base nitrogen (TVB-N) levels, effectively distinguishing fresh, sub-fresh, and spoiled samples. RGB analysis using a smartphone enabled rapid, on-site freshness evaluation. This dual-mode, printable sensing platform offers a practical and scalable approach for seafood freshness monitoring and intelligent food packaging.
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Colorimetric oxygen indicator films based on β-cyclodextrin grafted chitosan/montmorillonite with redox system for intelligent food packaging
(2022-06-01)
Jarupatnadech, Thanatcha
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Chalitangkoon, Jongjit
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Monvisade, Pathavuth
Oxygen is an important factor in food deterioration; thus, packaging, with an in-built oxygen indicator, has been widely developed. Here, a safer, natural product-based, colorimetric oxygen indicator film based on β-cyclodextrin grafted chitosan/montmorillonite with methylene blue/glucose system was fabricated. Methylene blue in the activated films was reduced to leuco-form (colourless) by glucose and reverted to blue with oxygen exposure. Glucose, as well as the reducing agent for methylene blue, crosslinked the chitosan. In addition, the grafting of β-cyclodextrin onto chitosan and the addition of montmorillonite as well as humidity led to the faster colour changes of the films. The colour recovery of films could delay by covering them with a poly(ethylene terephthalate) (PET) film. The activated films showed good storage stability at low temperature which is suitable for the package of refrigerated food products. The films had the potential to be used as natural-based colorimetric oxygen indicators for food packaging.

Monvisade, Pathavuth

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