Monvisade, Pathavuth

Preferred name

Alternative Name

Monvisade, P.

Main Affiliation

School of Science

pathavuth.mo@kmitl.ac.th

Now showing 1 - 6 of 6

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Photocrosslinked Poly(Vinyl Alcohol)–Tung Oil–Natural Rubber Films: A Sustainable Solution for Enhanced Water Resistance and Mechanical Properties in Biodegradable Packaging
(2025-06-20)
Monvisade, Pathavuth
;
Jianprasert, Apichaya
;
Sintoppun, Tanaporn
;
Yamaguchi, Masayuki
;
Rukchonlatee, Suparat
This study introduces a novel approach to addressing the water resistance limitations of poly(vinyl alcohol) (PVA)-based biodegradable films by developing a ternary blend system incorporating tung oil (T) and natural rubber (R), forming PTR films. Photocrosslinking, combined with thermal and redox catalytic systems, facilitated the creation of enhanced network structures, as confirmed by FTIR analysis, particularly at tung oils conjugated double bonds. Dynamic mechanical analysis (DMA) revealed significant shifts in glass transition temperatures (T<inf>g</inf>), signifying enhanced crosslink density and interconnectivity between the components. The resulting PTR films demonstrated remarkable improvements in water resistance, evidenced by higher solid remain percentages, reduced water absorption, and significantly lower water vapor permeability (WVP). Mechanical properties, including tensile strength and Youngs modulus, improved by up to 150% (from 6.6 MPa of PT0R15-r-np to 16.3 MPa of PT0R15-r-p30) and 870% (from 6.6 MPa of PT0R15-r-np to 16.3 MPa of PT0R15-r-p30), respectively, due to the formation of robust network structures. Contact angle measurements and reduced moisture content further underscored the enhanced hydrophobic and moisture barrier properties. These findings establish photocrosslinked PTR films as a sustainable and high-performance option for biodegradable packaging applications, offering practical advantages such as reduced processing temperatures and production times.
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Development of Bilayer Chitosan–Carrageenan Hydrogel Film for Enhanced Controlled Release of Turmeric–β-Cyclodextrin Complex in Wound Dressings
(2025-11-01)
Monvisade, Pathavuth
;
Sintoppun, Tanaporn
;
Chantaranara, Prapassorn
;
Punpairoj, Prapaporn
;
Deatvakkanee, Pitchapa
This study presents the development and evaluation of a bilayer hydrogel film designed for controlled drug delivery in wound dressing applications. The outer layer, composed of chitosan and glycerol, exhibited excellent water resistance, flexibility, and favorable moisture-handling properties, including high water vapor permeability and moisture absorption, which are critical factors for maintaining an optimal wound environment. The inner drug-loaded layer, formulated with carrageenan and loaded with either free turmeric or turmeric–β-cyclodextrin inclusion complex (TCD), served as the drug reservoir. Films incorporating TCD exhibited significantly enhanced turmeric solubility and drug release efficiency compared to those containing uncomplexed turmeric. Among the tested formulations, CS-TCD1, which featured a thinner drug-loaded layer, achieved the highest performance, with approximately 68% cumulative release over four days. While the release kinetics showed a strong correlation with the Higuchi kinetic model (R2 = 0.9927), further analysis using the Akaike Information Criterion (AIC) and the Korsmeyer–Peppas model indicated an anomalous (non-Fickian) transport mechanism, governed by both diffusion and matrix swelling or erosion. These results highlight the importance of matrix architecture and drug solubilization strategies in the design of hydrogel-based drug delivery systems for wound care.
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Dual covalent and ionic crosslinked xanthan gum–PVA hydrogel films for enhanced drug release performance
(2025-11-01)
Monvisade, Pathavuth
;
Napradit, Sasipa
;
Sintoppun, Tanaporn
;
Yamaguchi, Masayuki
This study presents the development and characterization of dual crosslinked xanthan gum–polyvinyl alcohol (XP) hydrogel films for potential use in controlled drug delivery applications. Hydrogel films were synthesized using glutaraldehyde for covalent crosslinking and Cu2+ ions for ionic crosslinking, with varying polymer ratios and crosslinker concentrations. The swelling behavior and gel content were evaluated in both distilled water at 25 °C and simulated body fluid (SBF) at 37 °C, revealing that dual crosslinking significantly enhanced structural integrity and swelling resistance, with gel content reaching up to 98%. Thermal analysis using DSC and DMA confirmed increased glass transition temperatures, indicating reduced polymer chain mobility due to denser crosslinking networks. Mechanical tests showed that the films possessed high tensile strength (60–62 MPa), with stiffness increasing alongside Cu2+ concentration and xanthan content. Cytocompatibility was validated through MTT assays on Vero cells, with all formulations exceeding 80% viability, thus classified as non-cytotoxic according to ISO 10993-5:2009 guidelines. Drug release studies using para-acetylaminophenol demonstrated sustained release behavior, achieving 50% release over 6 h in SBF. Kinetic analysis revealed that the release followed zero-order kinetics (R² = 0.9986) and case-II transport (n = 1.0396), indicating that release was governed by matrix swelling and erosion. These findings highlight the potential of XP dual crosslinked hydrogels as effective and biocompatible platforms for sustained drug delivery, particularly in wound care applications.
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Advanced chitosan hybrid dye labels for dynamic monitoring of shrimp and milk freshness
(2025-04-01)
Ronte, Arnat
;
Chalitangkoon, Jongjit
;
Sintoppun, Tanaporn
;
Niemhom, Nantawan
;
Manapradit, Nuttaporn
This study presents the development of intelligent screen-printed labels for real-time food freshness monitoring. Using chitosan grafted with rosolic acid (RA) and immobilized on montmorillonite (MMT) through cationic exchange, a hybrid dye was synthesized and applied in screen-printing inks. The hybrid structure was characterized by XRD, TGA, and UV–vis, confirming improved thermal stability and maintained halochromic properties. SEM analysis showed consistent ink deposition on filter paper, while water contact angle (WCA) measurements demonstrated enhanced surface hydrophobicity due to the MMT. The labels exhibited clear pH-sensitive color transitions from yellow to purplish red (pH 2.0–12.0) and rapid ammonia sensitivity, with ΔE values exceeding 45.0 within 10 min. The labels also demonstrated excellent reversibility, storage stability, leaching resistance, and cytocompatibility. Practical tests on shrimp and milk confirmed the labels' ability to accurately monitor freshness through visible color changes. These findings highlight the potential of hybrid labels as effective, scalable freshness indicators for intelligent food packaging.
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Dual Cross-Linked Chitosan-Based Films with pH-Sensitive Coloration and Drug Release Kinetics for Smart Wound Dressings
(2025-03-04)
Chalitangkoon, Jongjit
;
Ronte, Arnat
;
Sintoppun, Tanaporn
;
Manapradit, Nuttaporn
;
Monvisade, Pathavuth
In this study, we developed dual-cross-linked hydrogel films based on carboxyethyl chitosan (CECS) and sodium alginate (SA), utilizing dialdehyde β-cyclodextrin (DA-βCD) and gluconic acid δ-lactone (GDL) as cross-linkers. Designed as smart wound dressings, the films exhibit pH sensitivity due to the incorporation of carboxyethylated phenol red-grafted chitosan (CS-PR-AA), which allows them to change color from orange to purple in response to pH variations. FT-IR and TGA analyses confirmed the formation of imine bonds and polyelectrolyte complexes, indicating successful cross-linking. The films demonstrated high cell viability, confirming their biocompatibility and nontoxicity. The swelling behavior varied with pH, underscoring their adaptability to different wound environments. Additionally, drug release kinetics were studied for films incorporating diclofenac sodium (DCF) at various pH levels, revealing that the release rate was influenced by cross-linking density and environmental pH. These findings suggest that the dual-cross-linked hydrogel films have significant potential as smart wound dressings, offering controlled drug release and pH-responsive behavior suitable for wound care applications.
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Enhancing Structural Stability and Drug Release Control in Xanthan Gum–Poly(vinyl alcohol) Hydrogel Films via Ferric Ion Crosslinking
(2026-05-01)
Monvisade, Pathavuth
;
Napradit, Sasipa
;
Sintoppun, Tanaporn
;
Yamaguchi, Masayuki
This study investigates the development and characterization of xanthan gum/poly(vinyl alcohol) (XP) hydrogel films crosslinked with ferric ions via a dipping method for controlled oral drug delivery. The effects of ferric ion crosslinking on the physicochemical and mechanical properties of the films were systematically evaluated through swelling behavior, gel content, thermal and mechanical analyses, cytotoxicity testing, and in vitro drug release profiling using para-acetylaminophenol as a model drug under simulated digestive conditions. Crosslinking with ferric ions significantly enhanced the structural integrity of the films by reducing water uptake and improving gel stability in both simulated gastric (SGF) and intestinal fluids (SIF). Differential scanning calorimetry (DSC) and dynamic mechanical analysis (DMA) revealed restricted polymer chain mobility due to ionic interactions within the network. Mechanical testing showed increased tensile strength and Young’s modulus with higher crosslinking density. Cytotoxicity assays confirmed excellent biocompatibility, with high cell viability observed across all formulations. The films enabled controlled release of para-acetylaminophenol under simulated gastrointestinal conditions, with drug release kinetics suggesting a combination of diffusion-controlled and erosion-mediated mechanisms. These findings support the potential of Fe3+-crosslinked XP hydrogel films as stable and biocompatible carriers for sustained oral drug delivery.

Monvisade, Pathavuth

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