Monvisade, Pathavuth

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Preferred name
Monvisade, Pathavuth
Alternative Name
Monvisade, P.
Main Affiliation
Email
pathavuth.mo@kmitl.ac.th

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    Bacterial cellulose and bacterial cellulose/chitosan films containing mangosteen pericarp extract for wound dressings
    (2021-01-01)
    Moonsungnoen, Pronpatsorn
    ;
    Ochaikul, Duangjai
    ;
    Monvisade, Pathavuth
    Appropriate wound dressings for maintaining a moist wound environment, inducing re-epithelialization and protection from infection have been widely developed. Recently, many biocompatible polymers and bioactive substances have been extensively used for wound healing applications. In this study, bacterial cellulose film (BC-MPE film) and bacterial cellulose/chitosan film (BC/CH-MPE film) containing 1.56 mg/mL of mangosteen pericarp extract (MPE) were prepared. Antibacterial activity, cytotoxicity, physical and mechanical properties of the dry films were investigated. The BC film with MPE presented non-cytotoxic effect after 20 h of exposure to mouse fibroblast cell line (L929). The prepared films performed carrier of bioactive compounds that exhibited antibacterial activity against bacterial infection in burn wounds. The morphology of the films showed the characteristic of ultra-fine network structures with the entrapment of compounds. In addition, the compact structure was observed due to the rapid moisture loss during vacuum drying process. SEM images also showed that BC/CH-MPE film formed layers with chitosan entrapment causing the film to become thicker than BC-MPE film. The formation of MPE and chitosan in modified films was also confirmed by FTIR. The compact structure of BC/CH-MPE film led to the decrease in cumulative release of xanthone, WVTR and WAC. Moreover, the existence of chitosan in BC layers provided more flexible properties than the non-chitosan film. The chitosan addition demonstrated an influence of barrier film to protect the wound. Therefore, BC and chitosan were considered as suitable candidates for wound dressing material and xanthone content of MPE promoted wound healing as an effective therapeutic agent.
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    Development of Bilayer Chitosan–Carrageenan Hydrogel Film for Enhanced Controlled Release of Turmeric–β-Cyclodextrin Complex in Wound Dressings
    (2025-11-01)
    Monvisade, Pathavuth
    ;
    Sintoppun, Tanaporn
    ;
    Chantaranara, Prapassorn
    ;
    Punpairoj, Prapaporn
    ;
    Deatvakkanee, Pitchapa
    This study presents the development and evaluation of a bilayer hydrogel film designed for controlled drug delivery in wound dressing applications. The outer layer, composed of chitosan and glycerol, exhibited excellent water resistance, flexibility, and favorable moisture-handling properties, including high water vapor permeability and moisture absorption, which are critical factors for maintaining an optimal wound environment. The inner drug-loaded layer, formulated with carrageenan and loaded with either free turmeric or turmeric–β-cyclodextrin inclusion complex (TCD), served as the drug reservoir. Films incorporating TCD exhibited significantly enhanced turmeric solubility and drug release efficiency compared to those containing uncomplexed turmeric. Among the tested formulations, CS-TCD1, which featured a thinner drug-loaded layer, achieved the highest performance, with approximately 68% cumulative release over four days. While the release kinetics showed a strong correlation with the Higuchi kinetic model (R<sup>2</sup> = 0.9927), further analysis using the Akaike Information Criterion (AIC) and the Korsmeyer–Peppas model indicated an anomalous (non-Fickian) transport mechanism, governed by both diffusion and matrix swelling or erosion. These results highlight the importance of matrix architecture and drug solubilization strategies in the design of hydrogel-based drug delivery systems for wound care.
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    Synthesis of chitosan-based polymeric dyes as colorimetric pH-sensing materials: Potential for food and biomedical applications
    (2021-05-15)
    Chalitangkoon, Jongjit
    ;
    Monvisade, Pathavuth
    pH-sensitive polymeric dyes were fabricated by grafting phenol red (PR) and rosolic acid (RA) onto chitosan (CS) by a facile method. Successful grafting was confirmed by <sup>1</sup>H NMR, FT-IR, UV–vis, XRD, and elemental analysis. The polymeric dyes exhibited no cell toxicity. The colorimetric pH-sensing films were fabricated by blending the polymeric dyes with CS to establish their pH-dependent color properties. The film color changed in the pH range 4–10, which may indicate food spoilage or wound status. Covalently grafting of polymeric dyes in the films led to excellent color stability, leaching resistance, and reversibility. Hence, the synthesized polymeric dyes had potential as pH-indicative colorants for food and biomedical fields.