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    Microstructure and mechanical properties of Ti-Zr alloys fabricated by two-step spark plasma sintering from TiH2 and ZrH2 powders
    (2023-01-01)
    Banjongaxsorn, Kunpot
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    Khantachawana, Anak
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    Watanabe, Chihiro
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    Kondoh, Katsuyoshi
    Ti is well-known for its high strength-to-weight ratio and biocompatibility. It can be alloyed with Zr to improve mechanical properties. Currently, Ti-Zr alloys can be fabricated by powder metallurgy using Ti and Zr powders, although high oxidation reactivity and cost could still be an issue. In this study, premixed TiH<inf>2</inf> and ZrH<inf>2</inf> powders were used to prepare Ti-Zr binary alloys with different Zr contents of 0–30 mass% ZrH<inf>2</inf> via dehydrogenation and sintering by spark plasma sintering (SPS) process. α-Ti and δ-TiH<inf>2</inf> phases coexisted in the sintered Ti-Zr alloys, and a characteristic lamellar microstructure was formed. The tensile strength of the Ti-Zr alloys increased with increasing Zr content due to the solid solution effect, grain refinement and the appearance of δ-TiH<inf>2</inf> phases, although the elongation was reduced. This study shows that the fabricated Ti-Zr alloys possess controllable mechanical properties, which can be beneficial for biomedical and other engineering applications.
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    Effect of Nb Content and water quenching on microstructure and mechanical properties of Ti-Nb alloys fabricated by spark plasma sintering
    (2022-01-01)
    Suesawadwanid, Nattawood
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    Khantachawana, Anak
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    Kondoh, Katsuyoshi
    Titanium-niobium (Ti-Nb) alloys have been extensively studied for medical implants due to their advantageous mechanical properties and biocompatibility. However, the stress shielding effect remains a challenge. This research investigated the effects of Nb content and enhancement of α′′ formation on the mechanical properties of Ti-xNb alloys (x = 0, 5, 15 and 25%) fabricated by spark plasma sintering. Water quenching from the β phase induced α′′ phase formation in Ti-5Nb and Ti-15Nb samples, thereby reducing their Young’s modulus values but was not observed in commercially pure titanium (CP-Ti) and Ti-25Nb. Results showed that heat treatment with water quenching induced α′′ phase formation and can be used to tailor the properties of Ti-Nb alloys fabricated by SPS. This technique can also be used to enhance material ductility at high β-stabilizer content, as observed in Ti-25Nb samples.
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    Characterization of Fluoride-added Hydroxyapatite Derived from Eggshells for Dental Application
    (2023-01-01)
    Uthayaphamornwat, Vilasinee
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    Khantachawana, Anak
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    Hydroxyapatite (HA) is one of the potential biomaterials used for treating dental defects. It can be incorporated with fluoride to enhance its anti-caries properties, though other properties could be dependent on processing technique. Hence, this study aims to characterize the influence of sintering on the properties of fluoride-added HA derived from eggshells. FTIR and XRD techniques are used to characterize the chemical and crystal structures of the samples, whilst dissolution test is carried out to characterize material degradation in the acidic environment. The results show that sintering increased the crystallinity in both HA and fluoride-add HA (F-HA) samples, which corresponds with the enhanced stability during the dissolution test. Moreover, it is also found that the addition of fluoride could further stabilize the material structure, though the impurities found in all the samples still need to be minimized. These findings suggest that sintering and fluoride addition could potentially enhance anti-caries properties of eggshell-derived HA, which could be beneficial for dental application in future subject to further process optimization and analysis.
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    Influence of the Oxide Film on the Performance and Corrosion Resistance of TiNiCu Shape Memory Alloys as the Heat Engine Actuator
    (2024-10-01)
    Phukaoluan, Aphinan
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    Khantachawana, Anak
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    Chuchonak, Monthon
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    Shape memory alloys (SMAs) are utilized as an actuator for the heat engine to harvest energy from low-temperature geothermal sources, such as hot springs, which convert thermal energy into mechanical work. However, the alloy processing and engine design still require optimization to improve performance and durability. To discuss their potential as heat engine actuator, this study investigated the influence of oxide films on the TiNiCu SMAs in terms of surface and structural properties, recovery forces, and corrosion resistance. The results show that the surfaces of the etched samples were relatively coarser than those unetched with lower oxygen content. With the presence of oxide film, the Austenite Finish Temperature (Af) temperature of the unetched SMAs was lower with R-phase transformation. Also, it provided higher recovery force at above Af temperature (as high as 8.3 N at 70-mm displacement). Furthermore, the corrosion resistance of the unetched SMAs was higher than the etched samples, as analyzed by open-circuit potential and linear polarization in natural spring water at 70°C. These findings imply that the presence of oxide film could be beneficial for the SMAs when used as an actuator for heat engines, although it may require further study to investigate its impact on the fatigue behavior of the alloys.
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    Remote Temperature Monitoring for Infant Incubator using Thermal Camera
    (2022-01-01)
    Chuenpirom, Thanaporn
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    Health concerns over the premature babies are their immature organs and low birth weight. As a result, these babies may have difficulty in breathing, maintaining their healthy body temperature or being light sensitive. Infant incubator has been designed to overcome these issues. It is a medical device that could provide healthy environment, such as light, temperature and humidity. Moreover, it is also able to control and detect any changes which affect the baby's health. Health monitoring systems are critical in modern incubators, which could involve a set of sensors to read and send physiological information, such as temperature. It has also been proposed that establishing remote monitoring system via global system for mobile communications (GSM) would be beneficial for the incubators as it could send an alarm to the doctors and parents in the event that unhealthy vital parameters have been detected. Although a variety of vital parameters are included in the monitoring features of some modern incubators, the capability to detect body temperature of the babies are limited. Hence, this project proposes the development of an effective low-cost smart infant incubator that will benefit the body temperature monitoring of newborn babies using remote IoT-based monitoring system. The monitoring system is controlled through the use of a Raspberry Pi attached to a visual camera and a thermal IR camera with temperature sensor MLX90640, which was able to measure the body temperature remotely. The software of this smart infant incubator was used to improve monitoring system, which involves image processing techniques. The results of measured ambient temperature were found to be accurate and reliable. The prototypical incubator has been designed and manufactured with affordable cost, and the control system of the incubator was able to work comparably to other incubators with potential capability to measure body temperature of the infant.
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    Electroactive 3D printed scaffolds based on percolated composites of polycaprolactone with thermally reduced graphene oxide for antibacterial and tissue engineering applications
    (2020-03-01)
    Angulo-Pineda, Carolina
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    Palma, Patricia
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    Fuenzalida, Victor M.
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    Cartmell, Sarah H.
    Applying electrical stimulation (ES) could affect different cellular mechanisms, thereby producing a bactericidal effect and an increase in human cell viability. Despite its relevance, this bioelectric effect has been barely reported in percolated conductive biopolymers. In this context, electroactive polycaprolactone (PCL) scaffolds with conductive Thermally Reduced Graphene Oxide (TrGO) nanoparticles were obtained by a 3D printing method. Under direct current (DC) along the percolated scaffolds, a strong antibacterial effect was observed, which completely eradicated S. aureus on the surface of scaffolds. Notably, the same ES regime also produced a fourfold increase in the viability of human mesenchymal stem cells attached to the 3D conductive PCL/TrGO scaffold compared with the pure PCL scaffold. These results have widened the design of novel electroactive composite polymers that could both eliminate the bacteria adhered to the scaffold and increase human cell viability, which have great potential in tissue engineering applications.
      1
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    Comparative study of vacuum arc-remelting and spark plasma sintering processes on microstructure and corrosion behavior of Cp-Ti for biomedical implant applications
    (2025-11-01)
    Kunbuala, Neeraphat
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    Phamornnak, Chinnawich
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    Hankoy, Montree
    Titanium (Ti) and its alloys are widely used for biomedical applications due to their excellent mechanical properties and biocompatibility. However, the selection of an appropriate manufacturing process is critical to ensuring the optimal performance of Ti-based implants. This study investigates the effects of two fabrication methods –vacuum arc remelting (VAR) and spark plasma sintering (SPS) – on the microstructure and corrosion behavior of commercially pure titanium (Cp-Ti). VAR-Ti ingots were fabricated using arc-melting with multiple remelting cycles, whereas SPS-Ti specimens were sintered from Ti powders under pressure and pulsed current in a high-vacuum environment. Both specimens were subsequently heat-treated at 800 °C and furnace cooled. Microstructural characterization revealed coarser grains and porosity in VAR-Ti, while SPS-Ti showed refined, uniform α-phase structures. Electrochemical tests, including OCP, polarization, EIS, and ICP-MS, indicated slightly enhanced corrosion resistance in SPS-Ti, attributed to its defect-free microstructure. XPS analysis confirmed TiO<inf>2</inf> surface formation on both samples. Additionally, both materials exhibited high ductility and excellent biocompatibility, with cell viability exceeding ISO 10993-5 thresholds. These findings highlight the advantage of SPS in producing defect-minimized Cp-Ti with improved corrosion behavior for biomedical applications.
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    Thermomechanical performance of the offset crankshaft heat engine driven by tinicu shape memory alloys
    (2021-01-01) ;
    Khantachawana, Anak
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    Hok, Bunheng
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    Phukaoluan, Aphinan
    Geothermal hot springs are among the alternative clean energy sources to the fossil fuels for mitigating the current global warming crisis. However, the accessible geothermal water at the surface was mostly at low temperature, which impairs the practicality of harvesting these energy. Shape memory alloys (SMAs), which deform through the increased temperature, were adapted into the rotating mechanism as the actuators with the aims to convert the low-temperature heat into the mechanical work. This study utilized the helical spring-shaped TiNiCu SMAs as the actuators for the offset crankshaft heat engine. Performance of this engine was evaluated using rope brake dynamometer, by which the rotational speed, torque, and power were measured at the water temperature from 55-85°C. The results show that the engine performance increased with increasing water temperature and was dependent on the crankshaft arrangement. The offset angle of 30° was found to be optimal in this study with maximum torque of more than 5.8 N∙m and maximum power of 3.9 W at 15.7 rpm when operating at water temperature of 85°C. This study shows that the heat engine driven by TiNiCu SMAs could harvest low-temperature energy from the geothermal hot springs with the maximum observable efficiency of around 1.4%.
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    Co-stimulation with piezoelectric PVDF films and low intensity pulsed ultrasound enhances osteogenic differentiation
    (2025-08-01)
    Tandon, Biranche
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    Aguilar Cosme, Jose R.
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    Xue, Ruikang
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    Aguilar-Tadeo, Julio
    Bone tissue engineering has emerged as a promising approach to address the challenges of bone fracture repair and regeneration. The application of external stimuli (mechanical and electrical) can drive specific cellular responses and osteogenic differentiation, leading to the development of more effective treatments. Piezoelectric materials modulate cellular proliferation and osteogenic differentiation under both static (without mechanical stimulation) and dynamic (with mechanical stimulation) conditions, activating distinct gene expression pathways. In this work, we investigate the combinatorial effect of poly (vinylidene fluoride) (PVDF) poled and non-poled films, and low-intensity pulsed ultrasound (LIPUS) on early-stage osteogenic differentiation of mouse pre-osteoblasts. Static culture with PVDF poled films enhanced Runx2 and Col1α1 expression without impacting alkaline phosphatase (ALP) activity. Inhibition of ERK phosphorylation using U0126 in PVDF poled films resulted in a ~ 6–8-fold increase in ALP activity, suggesting the involvement of an alternative pathway in osteogenic differentiation. Dynamic culture with LIPUS generated an electric potential of approximately 500 mV across PVDF films and an electrical field of 0–10 mV mm<sup>−1</sup>. Co-stimulation led to a ~3-fold increase of ALP activity on stimulated PVDF compared to unstimulated films. This study underscores the potential of piezoelectric materials as non-invasive electrical stimulators to enhance the efficacy of ultrasound-based therapies for bone fracture repair.
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    Assessment of the utility of chitosan nanoparticles and microfibers in drug delivery applications of sulfamethoxazole and ciprofloxacin
    (2025-05-07)
    Soontorntepwarakul, Nussara
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    Fukasem, Poowadon
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    Somkhuan, Sitthinan
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    The objective of this research was to explore the suitability of chitosan (CS) in the form of nanoparticles (NP) and microfibres (MF) for oral delivery applications related to low solubility antibiotic drugs sulfamethoxazole and ciprofloxacin. The ionic gelation method in conjunction with freeze-drying was used to produce crosslinked chitosan material. The dynamic light scattering (DLS) technique was used to characterize the particle size and polydispersity index (PDI). Surface morphology was analyzed using scanning electron microscopy (SEM). The antibiotic drugs ciprofloxacin (CPF) and sulfamethoxazole (SMO) were loaded onto the chitosan nanoparticle and microfibre materials. The degree of loading and the release kinetics were investigated using high-performance liquid chromatography (HPLC) and a UV-visible spectrophotometer, respectively. CS itself has mucoadhesive properties and combined with the more rapid release of drug compared to the pure API, or traditional tablet formulations, CS nanoparticles and microfibres have the potential to improve the delivery properties of CPF and also SMO to a lesser extent. This difference can be rationalized on account of their differing physicochemical properties.
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