Srirussamee, Kasama

Preferred name

Srirussamee, Kasama

Main Affiliation

School of Engineering

kasama.sr@kmitl.ac.th

Now showing 1 - 10 of 19

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Electroactive 3D printed scaffolds based on percolated composites of polycaprolactone with thermally reduced graphene oxide for antibacterial and tissue engineering applications
(2020-03-01)
Angulo-Pineda, Carolina
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Srirussamee, Kasama
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Palma, Patricia
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Fuenzalida, Victor M.
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Cartmell, Sarah H.
Applying electrical stimulation (ES) could affect different cellular mechanisms, thereby producing a bactericidal effect and an increase in human cell viability. Despite its relevance, this bioelectric effect has been barely reported in percolated conductive biopolymers. In this context, electroactive polycaprolactone (PCL) scaffolds with conductive Thermally Reduced Graphene Oxide (TrGO) nanoparticles were obtained by a 3D printing method. Under direct current (DC) along the percolated scaffolds, a strong antibacterial effect was observed, which completely eradicated S. aureus on the surface of scaffolds. Notably, the same ES regime also produced a fourfold increase in the viability of human mesenchymal stem cells attached to the 3D conductive PCL/TrGO scaffold compared with the pure PCL scaffold. These results have widened the design of novel electroactive composite polymers that could both eliminate the bacteria adhered to the scaffold and increase human cell viability, which have great potential in tissue engineering applications.
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Remote Temperature Monitoring for Infant Incubator using Thermal Camera
(2022-01-01)
Chuenpirom, Thanaporn
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Srirussamee, Kasama
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Pintavirooj, Chuchart
Health concerns over the premature babies are their immature organs and low birth weight. As a result, these babies may have difficulty in breathing, maintaining their healthy body temperature or being light sensitive. Infant incubator has been designed to overcome these issues. It is a medical device that could provide healthy environment, such as light, temperature and humidity. Moreover, it is also able to control and detect any changes which affect the baby's health. Health monitoring systems are critical in modern incubators, which could involve a set of sensors to read and send physiological information, such as temperature. It has also been proposed that establishing remote monitoring system via global system for mobile communications (GSM) would be beneficial for the incubators as it could send an alarm to the doctors and parents in the event that unhealthy vital parameters have been detected. Although a variety of vital parameters are included in the monitoring features of some modern incubators, the capability to detect body temperature of the babies are limited. Hence, this project proposes the development of an effective low-cost smart infant incubator that will benefit the body temperature monitoring of newborn babies using remote IoT-based monitoring system. The monitoring system is controlled through the use of a Raspberry Pi attached to a visual camera and a thermal IR camera with temperature sensor MLX90640, which was able to measure the body temperature remotely. The software of this smart infant incubator was used to improve monitoring system, which involves image processing techniques. The results of measured ambient temperature were found to be accurate and reliable. The prototypical incubator has been designed and manufactured with affordable cost, and the control system of the incubator was able to work comparably to other incubators with potential capability to measure body temperature of the infant.
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Microstructure and mechanical properties of Ti-Zr alloys fabricated by two-step spark plasma sintering from TiH2 and ZrH2 powders
(2023-01-01)
Banjongaxsorn, Kunpot
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Khantachawana, Anak
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Watanabe, Chihiro
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Srirussamee, Kasama
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Kondoh, Katsuyoshi
Ti is well-known for its high strength-to-weight ratio and biocompatibility. It can be alloyed with Zr to improve mechanical properties. Currently, Ti-Zr alloys can be fabricated by powder metallurgy using Ti and Zr powders, although high oxidation reactivity and cost could still be an issue. In this study, premixed TiH<inf>2</inf> and ZrH<inf>2</inf> powders were used to prepare Ti-Zr binary alloys with different Zr contents of 0–30 mass% ZrH<inf>2</inf> via dehydrogenation and sintering by spark plasma sintering (SPS) process. α-Ti and δ-TiH<inf>2</inf> phases coexisted in the sintered Ti-Zr alloys, and a characteristic lamellar microstructure was formed. The tensile strength of the Ti-Zr alloys increased with increasing Zr content due to the solid solution effect, grain refinement and the appearance of δ-TiH<inf>2</inf> phases, although the elongation was reduced. This study shows that the fabricated Ti-Zr alloys possess controllable mechanical properties, which can be beneficial for biomedical and other engineering applications.
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Effects of Surface Finishing Techniques on Properties of NiTi Coil Spring Actuators
(2025-01-01)
Premwattananarakul, Natakorn
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Srirussamee, Kasama
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Tunthawiroon, Phacharaphon
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Kumnorkaew, Theerawat
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Phukaoluan, Aphinan
This research aims to investigate the effects of surface finishing techniques on phase transformation, topography, and recovery force of NiTi coil springs designed for actuator applications. The NiTi wire, with a diameter of 1 mm, was fabricated into a helical spring with an index of 9 and 20 active coils. The spring was subsequently annealed at 550 °C for 30 min and then quenched in water. The surface finishing techniques applied to the NiTi springs included chemical etching, mechanical polishing, and sand blasting. It was observed that mechanical polishing had a strong impact on topography than both chemical etching and sand blasting. After mechanical polishing, the topography of NiTi coil springs slightly changed compared to the annealed spring. The examined surface was smooth and glistening, with a surface roughness R<inf>a</inf> of 0.175 ± 0.006 µm, nearly identical to that of the annealed spring R<inf>a</inf> of 0.116 ± 0.021 µm. Chemical etching produced a surface oxide, yet the surface became rough due to an uncontrollable chemical reaction, i.e., the R<inf>a</inf> value obtained from chemical etched surface (1.177 ± 0.156 µm) was higher than that of the mechanically polished spring. Meanwhile, sand blasting provided a blue-shaded surface corresponding to an excessive R<inf>a</inf> of 1.952 ± 0.204 µm. The DSC results revealed two peaks of R-phase and martensite transformation in the cooling curve, with only austenite transformation appearing on the heating curve. According to the DSC curve, all surface finishing techniques can reduce the latent heat and affect the associated phase transformations. Consequently, the recovery force of the spring was increased by 2–5 times the initial length. The maximum stiffness (k) of 0.129 N/mm and recovery force for the surface-finished springs were provided by mechanical polishing, while the minimum values of 0.104 N/mm were yielded by sand blasting. All experimental findings offer a framework for the development of actuator springs enhanced through each surface finishing technique.
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Assessment of the Utility of Chitosan in Drug Delivery of Sulfamethoxazole
(2024-01-01)
Soontorntepwarakul, Nussara
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Boonyarattanakalin, Kanokthip
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Srirussamee, Kasama
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Paul Gleeson, M.
The objective of this research was to develop chitosan (CS) nanoparticles (NP) and microfibres (MF) for oral delivery applications related to low solubility drugs. The ionic gelation method in conjunction with freeze-drying was used to produce crosslinked chitosan material. Dynamic light scattering (DLS) was used to characterize particle size and polydispersity index (PDI). Surface morphology was analyzed using scanning electron microscopy (SEM). The antibiotic drug sulfamethoxazole (SMO) was loaded onto the chitosan nano/micro material. The degree of loading, loading efficiency and the release kinetics were investigated using high-performance liquid chromatography (HPLC) and UV-visible spectrophotometry, respectively. We found that CS nanoparticles have the potential to improve the delivery properties of SMO due to their more rapid release compared to microfibres or traditional tablet formulations.
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Changes in the extracellular microenvironment and osteogenic responses of mesenchymal stem/stromal cells induced by in vitro direct electrical stimulation
(2021-01-01)
Srirussamee, Kasama
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Xue, Ruikang
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Mobini, Sahba
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Cassidy, Nigel J.
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Cartmell, Sarah H.
Electrical stimulation (ES) has potential to be an effective tool for bone injury treatment in clinics. However, the therapeutic mechanism associated with ES is still being discussed. This study aims to investigate the initial mechanism of action by characterising the physical and chemical changes in the extracellular environment during ES and correlate them with the responses of mesenchymal stem/stromal cells (MSCs). Computational modelling was used to estimate the electrical potentials relative to the cathode and the current density across the cell monolayer. We showed expression of phosphorylated ERK1/2, c-FOS, c-JUN, and SPP1 mRNAs, as well as the increased metabolic activities of MSCs at different time points. Moreover, the average of 2.5 μM of H<inf>2</inf>O<inf>2</inf> and 34 μg/L of dissolved Pt were measured from the electrically stimulated media (ES media), which also corresponded with the increases in SPP1 mRNA expression and cell metabolic activities. The addition of sodium pyruvate to the ES media as an antioxidant did not alter the SPP1 mRNA expression, but eliminated an increase in cell metabolic activities induced by ES media treatment. These findings suggest that H<inf>2</inf>O<inf>2</inf> was influencing cell metabolic activity, whereas SPP1 mRNA expression was regulated by other faradic by-products. This study reveals how different electrical stimulation regime alters cellular regenerative responses and the roles of faradic by-products, that might be used as a physical tool to guide and control cell behaviour.
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Characterization of oxide films on wrought Co–Cr–Mo–xSi alloys exposed to high-temperature oxidation
(2021-10-01)
Tunthawiroon, Phacharaphon
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Kitiwan, Mettaya
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Srirussamee, Kasama
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Li, Yunping
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Yamanaka, Kenta
Co-based alloys are currently being used in a wide range of high temperature applications owing to their high resistance to oxidation and corrosion. However, their oxidation-induced degradation could still occur during the long-term exposure to high temperature. Thus, the continuous development of oxidation-resistant Co-based alloys is of crucial importance. In this research, the influence of Si addition on the oxidation behavior of Co–Cr–Mo–xSi alloys under the isothermal oxidation treatment at 700 °C in air was investigated. The Si concentration (x) was varied from 0.1 to 5.0 wt.%. Surface morphologies and chemical compositions of the oxide films formed were analyzed by using SEM-EDS and XPS. The chemical compositions obtained from the surface analysis revealed that Si has played a role in the stabilization of Cr oxides on the surface of Co–Cr–Mo–xSi alloys. With increasing Si concentration, Co-oxide formation on the alloy surface was suppressed by the presence of Cr-oxide due to the selective oxidation of Cr atoms. Furthermore, SiO<inf>2</inf> was both found along the grain boundaries and interfaces between the outmost oxide layer and matrix. It was also found that the oxide thickness was reduced with increasing Si concentration. This was a result of the formation of stable Cr-oxide and SiO<inf>2</inf> sub-layer that became a barrier inhibiting the inward and outward diffusion of O and Cr.
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Assessment of the utility of chitosan nanoparticles and microfibers in drug delivery applications of sulfamethoxazole and ciprofloxacin
(2025-05-07)
Soontorntepwarakul, Nussara
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Boonyarattanakalin, Kanokthip
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Fukasem, Poowadon
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Somkhuan, Sitthinan
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Srirussamee, Kasama
The objective of this research was to explore the suitability of chitosan (CS) in the form of nanoparticles (NP) and microfibres (MF) for oral delivery applications related to low solubility antibiotic drugs sulfamethoxazole and ciprofloxacin. The ionic gelation method in conjunction with freeze-drying was used to produce crosslinked chitosan material. The dynamic light scattering (DLS) technique was used to characterize the particle size and polydispersity index (PDI). Surface morphology was analyzed using scanning electron microscopy (SEM). The antibiotic drugs ciprofloxacin (CPF) and sulfamethoxazole (SMO) were loaded onto the chitosan nanoparticle and microfibre materials. The degree of loading and the release kinetics were investigated using high-performance liquid chromatography (HPLC) and a UV-visible spectrophotometer, respectively. CS itself has mucoadhesive properties and combined with the more rapid release of drug compared to the pure API, or traditional tablet formulations, CS nanoparticles and microfibres have the potential to improve the delivery properties of CPF and also SMO to a lesser extent. This difference can be rationalized on account of their differing physicochemical properties.
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Comparative study of vacuum arc-remelting and spark plasma sintering processes on microstructure and corrosion behavior of Cp-Ti for biomedical implant applications
(2025-11-01)
Kunbuala, Neeraphat
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Srirussamee, Kasama
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Phamornnak, Chinnawich
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Tunthawiroon, Phacharaphon
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Hankoy, Montree
Titanium (Ti) and its alloys are widely used for biomedical applications due to their excellent mechanical properties and biocompatibility. However, the selection of an appropriate manufacturing process is critical to ensuring the optimal performance of Ti-based implants. This study investigates the effects of two fabrication methods –vacuum arc remelting (VAR) and spark plasma sintering (SPS) – on the microstructure and corrosion behavior of commercially pure titanium (Cp-Ti). VAR-Ti ingots were fabricated using arc-melting with multiple remelting cycles, whereas SPS-Ti specimens were sintered from Ti powders under pressure and pulsed current in a high-vacuum environment. Both specimens were subsequently heat-treated at 800 °C and furnace cooled. Microstructural characterization revealed coarser grains and porosity in VAR-Ti, while SPS-Ti showed refined, uniform α-phase structures. Electrochemical tests, including OCP, polarization, EIS, and ICP-MS, indicated slightly enhanced corrosion resistance in SPS-Ti, attributed to its defect-free microstructure. XPS analysis confirmed TiO<inf>2</inf> surface formation on both samples. Additionally, both materials exhibited high ductility and excellent biocompatibility, with cell viability exceeding ISO 10993-5 thresholds. These findings highlight the advantage of SPS in producing defect-minimized Cp-Ti with improved corrosion behavior for biomedical applications.
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Fabrication of Water-insoluble Polyethylene Oxide and Sodium Alginate using Electrostatic Repulsive Forces: A Preliminary Study
(2023-01-01)
Niyomchon, Phuphinee
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Srirussamee, Kasama
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Treebupachatsakul, Treesukon
Polyethylene oxide (PEO) and sodium alginate (NaAlg) are widely used in biomedical applications due to their biocompatibility. The use of electrostatic repulsive forces could be employed to fabricate these polymers into various shapes, including fibers and particles. However, in some cases, their solubility in water could be a drawback. Therefore, this study aims to fabricate samples from PEO-NaAlg blends using electrostatic repulsive forces and stabilize their structure in water using calcium chloride (CaCl<inf>2</inf>) crosslinking method. The preliminary results have shown that the water solubility of the fabricated samples in this study was reduced by crosslinking, as analyzed by Fourier-transform spectroscopy (FTIR). Moreover, the images from scanning electron microscope (SEM) reveal that the fabricated samples were particle-like, and the increased NaAlg content could increase fiber density before crosslinking and particle aggregate formation after crosslinking. However, further studies are still required to optimize the parameters for fiber fabrication and also for future incorporation of bioactive molecules.

Srirussamee, Kasama

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