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Subject: search.filters.subject.Nanoemulsion

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    Stable Nanoemulsion System Development Enabling the Topical Delivery of Synechococcus-Derived Peptides
    (2026-03-01)
    Keawbankrud, Wannisa
    ;
    Nakyai, Wongnapa
    ;
    Phunpruch, Saranya
    ;
    Sangtanoo, Papassara
    ;
    Karnchanatat, Aphichart
    Marine microalgae including Synechococcus sp. VDW offer the potential to serve as a source of bioactive peptides offering valuable antioxidant and antimelanogenic qualities for use in the pharmaceutical and cosmetics industries. At present, however, the use of such peptides is challenging due to their poor physicochemical stability. This research therefore sought to achieve the production and characterization of a stable nanoemulsion system based upon the use of synthetic Synechococcus-derived peptides through the process of high-pressure homogenization (HPH). Preparation of the nanoemulsions involved the use of Tween-80 and caprylic/capric triglyceride at a pressure of 7,500 psi to perform homogenization for varying durations of 15, 30 and 45 min. Using the optimized formulation with 0.1% w/w peptide for a time of 45 min resulted in 122.16 nm droplets while the zeta potential was −80.09 mV and the PDI (polydispersity index) value was 0.13. Colloidal stability could be considered high, while physical stability under thermal cycling, centrifugation and freeze-thaw cycles was very good, with no phase separation. For all testing intervals, the viscosity and refractive index were stable. It can thus be argues that the HPH approach is suitable to produce peptide-loaded nanoemulsions offering good stability and useful physicochemical characteristics. The developed nanoemulsion system has been optimized to offer potential for applications involving the transdermal delivery of marine peptides in the cosmeceutical sector and for a range of dermal therapies.
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    The effectiveness of star anise nanoemulsion and chemical insecticide for controlling of beet armyworm
    (2024-05-01)
    Passara, H.
    ;
    Pumnuan, J.
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    Thongsaiklaing, T.
    ;
    Thipmanee, K.
    The effectiveness of star anise (Illicium verum) nanoemulsion and deltamethrin (chemical insecticide) was tested with beet armyworm (Spodoptera exigua) to evaluate their mortality, antifeedant, and growth inhibition effects at proper concentrations. As a result, at the obtained highest effectiveness, star anise nanoemulsion required 0.35% concentration for the maximum effectiveness with 100% mortality, antifeedant and growth inhibition effects against beet armyworm, when compared with the control (Tween20 and water), while deltamethrin exhibited a lower rate. Therefore, star anise nanoemulsion seem to be utilized as a highly effective and environmentally friendly insecticide to control beet armyworm.
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    Insecticidal efficiency of plant essential oil nanoemulsion formulas against Spodoptera exigua
    (2024-01-01)
    Passara, H.
    ;
    Pumnuan, J.
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    Thongsaiklaing, T.
    ;
    Thipmanee, K.
    The findings revealed that the nEO formula of I. verum and C. longa demonstrated optimal effectiveness, with a concentration of 0.35% resulting in the highest mortality rate of 43.3%, 100% antifeedant effect and 85.0% growth inhibition activities in pupae. Additionally, a concentration of 0.25% led to 100% growth inhibition activities in adults. Consequently, the nEO formulas of I. verum and C. longa promise for the future development of botanical insecticides targeting the control of S. exigua.
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    Insecticidal effect of plant essential oil nanoemulsions on controlling Spodoptera exigua
    (2023-03-01)
    Passara, H.
    ;
    Pumnaun, J.
    ;
    Thipmanee, K.
    The results showed that Curcuma longa and Illicium verum nEOs performed extremely high mortality and antifeedant activity, as well as affected on growth development of Spodoptera exigua. Essential oil nanoemulsions at 0.35 % concentrations caused 100% mortality, 100% antifeedant activity, and 100% growth inhibition. Curcuma longa and Illicium verum nEOs revealed to be used as botanical insecticide for controlling Spodoptera exigua.
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    Evaluating the acaricidal effect of essential oil nanoemulsion against the cutworm, Spodoptera litura
    (2022-09-01)
    Passara, H.
    ;
    Pumnaun, J.
    ;
    Thipmanee, K.
    The cutworm, Spodoptera litura is an important pest of cruciferous vegetables and it causes economic impact worldwide. The efficiency of turmeric and star anise essential oil nanoemulsions (nEOs) against the cutworm, including mortality, antifeedant, and growth inhibition effects was investigated. Essential oil nanoemulsions (nEOs) were prepared by mixing the essential oils with surfactants and co-surfactants. The 2<sup>nd</sup>, stage instar larvae of cutworms were tested by leaf dipping method and were observed after 24 hours. The results showed that the two nEOs, which were turmeric and star anise, performing the mortality, and growth development effect on Spodoptera litura as well as having antifeedant property. Complete mortality rate was shown at 0.35 % concentration of turmeric and star anise nEOs, when 100% antifeedant effect was found at 0.20% concentrations of nEOs, and 100% growth inhibition was observed at 0.30% concentrations of nEOs. It could be concluded that the nEOs from star anise had antifeedant and insecticide properties.
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    Improving Stability of Nanoemulsion Containing Centella asiatica, Lycopersicon Esculentum Mil. And Moringa oleifera Lam. Extract
    (2019-01-01)
    Limthin, Darawan
    ;
    Phromyothin, Darinee
    Natural extracts are interesting because those have bioactive compounds which can be used as antioxidants in pharmacological cosmetics. However, bioactive compounds are unstable to environment. In the present study, formulation and stability of Centella asiatica, Lycopersicon Esculentum Mil. and Moringa oleifera Lam. was performed using high shear homogenization (HSH) technique. Virgin coconut oil was based of oil phase for emulsion. The optimum formulation of the nanoemulsion consisted of 80:10:10 of water, tween 80 and oil, respectively. 1 % of natural extract nanoemulsion was homogenized for 20 minutes at 4,000 rpm. and stored at 4 ºC, 25 ºC and 40 ºC for 7 days. Particles size and electrokinetic potential of emulsion extract was determined by dynamic light scattering method. Single-phase solution and droplet size was observed in the range of 100 to 500 nm. The droplet size and stability of emulsions depends on temperature and times storage, which this study would be approached to develop a natural product in cosmetic market.